Protective effect of regular physical activity on prostate cancer complications
الموضوعات : فیزیولوژی ورزشی
Fatemeh Jamshidirad
1
,
Hassan Matin Homaee
2
,
Mohammad Ali Azarbayjani
3
1 - Department of Exercise physiology, CT.C, Islamic Azad University, Tehran, Iran.
2 - Department of Exercise physiology, CT.C, Islamic Azad University, Tehran, Iran.
3 - Department of Physical Education and Sport Sciences, CT.C., Islamic Azad University, Tehran, Iran
الکلمات المفتاحية: Aerobic exercise, Resistance exercise, Prostate cancer,
ملخص المقالة :
Prostate cancer (PCa) is one of the leading causes of cancer-related mortality and morbidity
among men worldwide. Although the number of deaths from this cancer has decreased over the
past decade, the incidence of PCa continues to rise globally. In addition to non-modifiable risk
factors, modifiable risk factors such as diet, tobacco and alcohol consumption, obesity, and
physical inactivity play a significant role in the development of PCa. Daily physical activity is an
important factor in PCa risk, and incorporating it into the daily routine of healthy individua ls can
substantially reduce the likelihood of developing PCa, while in affected individuals, it can
significantly slow disease progression. Reviewing the results of studies investigating the effects
of various exercise programs on PCa demonstrates that regular physical activity can markedly
reduce the negative impacts of PCa. These changes occur both at the prostate tumor level,
slowing tumor growth, and can also modulate treatment-related side effects such as quality of
life (QoL), physical function capacity, muscle mass, sexual function, and fatigue. Regular physical
activity exerts its protective effects in PCa patients through improving metabolic status,
enhancing antioxidant defense capacity, increasing tumor growth-inhibiting myokines, and a
range of other biological mechanisms. Based on the findings of this study, it is recommended that
regular physical activity, particularly a combination of aerobic and resistance training, be
integrated as an essential component of the management process for individu als with PCa.
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